A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole

作者：Tebben Jan; Motti Cherie^*; Tapiolas Dianne; Thomas Hall Peter; Harder Tilmann

来源：Marine Drugs, 2014, 12(5): 2802-2815.

DOI：10.3390/md12052802

• Pseudoalteromonas
• korormicin
• bromopyrrole
• bromoalterochromide
• antibacterial
• antifungal
• antiprotozoal

The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products. These included a new bromopyrrole, 4'-((3,4,5-tribromo-1H-pyrrol-2-yl) methyl) phenol (1) and five new korormicins G-K (2-6). Also isolated was the known inducer of coral larval metamorphosis, tetrabromopyrrole (TBP), five known korormicins (A-E, previously named 1, 1a-c and 3) and bromoalterochromide A (BAC-A). Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The antibacterial, antifungal and antiprotozoal potential of 1-6, TBP and BAC-A was assessed. Compounds 1-6 showed antibacterial activity while BAC-A exhibited antiprotozoal properties against Tetrahymena pyriformis. TBP was found to have broad-spectrum activity against all bacteria, the protozoan and the fungus Candida albicans.

• 出版日期2014-5