科研之友
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摘要
The accelerated longitudinal bone growth at puberty or pubertal growth spurt has been ascribed to reciprocated physiological influences of both somatotropic and gonadal axes, manifested as higher secretion of growth hormone (GH) and testosterone (T) GH and T affect linear growth velocity (LGV) directly through stimulation of chondrocytes and osteoblasts Furthermore, T promotes LGV through augmentation of GH secretion Nevertheless, age and developmental stage dependent changes in GH and T and LGV and their associations require further investigation. This study examined relationships between GH and LGV, T and LGV and GB and T in 540 normal healthy boys of 1 to 20 years (n=27 boys/age group) The concentrations of GH and T were measured using specific ELISA systems and LGV was calculated for each age/stage group Pearson correlation r and ANOVA were employed. GH and LGV exhibited age related positive correlations from 1 to 20 years and developmental stage dependent positive correlations during infancy, pre-puberty, early, mid and late puberty/adolescence. T and LGV were positively correlated from 1st to 16th year and negatively correlated from 17th to 20th year. T and LGV exhibited positive correlations from infancy to mid-puberty and negative correlation at late puberty/adolescence. GH and T were positively correlated from 1 to 16 years and negatively correlated between 17 and 20 years GH and T were positively correlated during infancy, pre-puberty and early and mid-puberty and negatively correlated at late puberty/adolescence In conclusion, GH, T and LGV exhibit age and stage dependent changes from infancy to early adulthood
- 出版日期2017-2
