Ultrasound-promoted greener approach to synthesize alpha-hydroxy phosphonates catalyzed by potassium dihydrogen phosphate under solvent-free condition

作者：Mandhane Priyanka G; Joshi Ratnadeep S; Nagargoje Deepak R; Gill Charansingh H^*

来源：Tetrahedron Letters, 2010, 51(11): 1490-1492.

DOI：10.1016/j.tetlet.2010.01.031

• Potassium dihydrogen phosphate
• alpha-Hydroxyphosphonates
• Aldehydes
• Triethylphosphite
• Ultrasonication

We report a new environmentally-benign, convenient, and facile methodology for the synthesis of alpha-hydroxyphosphonates from an aromatic/heteroaromatic aldehyde with triethyl phosphite in the presence of potassium dihydrogen phosphate (KH(2)PO(4)) under ultrasound-assisted solvent-free conditions. Furthermore, a series of compounds were synthesized and characterized by melting point, El-MS, NMR, and IR tools. Utilization of easy reaction conditions, isolation, and purification makes this manipulation very interesting from an economic perspective.

• 出版日期2010-3-17