Medial prefrontal theta phase coupling during spatial memory retrieval

作者：Kaplan Raphael^*; Bush Daniel; Bonnefond Mathilde; Bandettini Peter A; Barnes Gareth R; Doeller Christian F; Burgess Neil

来源：Hippocampus, 2014, 24(6): 656-665.

DOI：10.1002/hipo.22255

• hippocampus
• mPFC
• MTL
• MEG
• oscillations

Memory retrieval is believed to involve a disparate network of areas, including medial prefrontal and medial temporal cortices, but the mechanisms underlying their coordination remain elusive. One suggestion is that oscillatory coherence mediates inter-regional communication, implicating theta phase and theta-gamma phase-amplitude coupling in mnemonic function across species. To examine this hypothesis, we used non-invasive whole-head magnetoencephalography (MEG) as participants retrieved the location of objects encountered within a virtual environment. We demonstrate that, when participants are cued with the image of an object whose location they must subsequently navigate to, there is a significant increase in 4-8 Hz theta power in medial prefrontal cortex (mPFC), and the phase of this oscillation is coupled both with ongoing theta phase in the medial temporal lobe (MTL) and perceptually induced 65-85 Hz gamma amplitude in medial parietal cortex. These results suggest that theta phase coupling between mPFC and MTL and theta-gamma phase-amplitude coupling between mPFC and neocortical regions may play a role in human spatial memory retrieval.

• 出版日期2014-6