New medical therapies of acromegaly

作者：Maffezzoni F; Frara S; Doga M; Mazziotti G; Giustina A^*

来源：Growth Hormone & IGF Research, 2016, 30-31: 58-63.

DOI：10.1016/j.ghir.2016.10.001

• Acromegaly
• Somatostatin analogs
• Pasireotide
• Oral octreotide
• Antisense molecules
• Botulin neurotoxin

Acromegaly is a rare disease associated with significant morbidity and increased mortality. Treatment of acromegaly aims at controlling growth hormone hypersecretion, improving patients' symptoms and comorbidities and normalizing mortality. The therapeutic options for acromegaly include surgery, medical therapies and radiotherapy. However, despite all these treatment options, approximately one-half of patients are not adequately controlled. Progress in molecular research has made possible to develop new therapeutic strategies to improve control of acromegaly. This article will review the new medical approaches to acromegaly which consist in evolution of traditional therapeutic protocols and development of new molecules with different profiles of activity.

• 出版日期2016-12