Distinct effects of dietary flax compared to fish oil, soy protein compared to casein, and sex on the renal oxylipin profile in models of polycystic kidney disease

作者：Devassy Jessay G; Yamaguchi Tamio; Monirujjaman Md; Gabbs Melissa; Ravandi Amir; Zhou Jing; Aukema Harold M

来源：Prostaglandins, Leukotrienes and Essential Fatty Acids, 2017, 123: 1-13.

DOI：10.1016/j.plefa.2017.07.002

• Oxylipins
• Bioactive lipids
• Kidney
• Soy protein
• N-3 fatty acids
• Fish oil
• Flax oil
• Sex

Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFA) that are important regulators of kidney function and health. Targeted lipidomic analyses of renal oxylipins from four studies of rodent models of renal disease were performed to investigate the differential effects of dietary flax compared to fish oil, soy protein compared to casein, and sex. Across all studies, dietary fish oil was more effective than flax oil in reducing n-6 PUPA derived oxylipins and elevating eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived oxylipins, whereas dietary flax oil resulted in higher a-linolenic acid (ALA) oxylipins. Dietary soy protein compared to casein resulted in higher linoleic acid (LA) derived oxylipins. Kidneys from females had higher levels of arachidonic acid (AA) oxylipins, but similar or lower levels of oxylipins from other PUPA. Modulation of the oxylipin profile by diet and sex may help elucidate their effects on renal physiology and health.

• 出版日期2017-8