A Green, One-Pot Synthesis of Substituted 2,3-Dihydroquinazoline-4(1H)-ones in the Presence of N-Sulfonic Acid Pyridinium Chloride

作者：Azimi Seyedeh Bahareh; Azizian Javad^*

来源：Synlett, 2016, 27(12): 1836-1839.

DOI：10.1055/s-0035-1561611

• three-component reaction
• N-sulfonic acid pyridinium chloride
• 2
• 3-dihydro-4(1H)-quinazolinones
• solvent-free
• green synthesis

We present a one-pot method for the synthesis of 2,3-dihydroquinazoline-4(1H)-ones. The three-component reaction between isatoic anhydride, primary amines, and dialkyl acetylenedicarboxylates in the presence of N-sulfonic acid pyridinium chloride under solvent-free conditions affords the corresponding alkyl 2-[(alkoxycarbonyl)methyl]-1,2,3,4-tetrahydro-3-alkyl-4-oxo-quinazoline-2-carboxylates in excellent yields.

• 出版日期2016-7