A novel synthesis of polysubstituted chromenes from various salicylaldehydes and alkynes under mild conditions

作者：Tanaka Kenta; Hoshino Yujiro; Honda Kiyoshi^*

来源：Tetrahedron Letters, 2016, 57(22): 2448-2450.

DOI：10.1016/j.tetlet.2016.04.086

• Substituted 2H-chromene
• o-Quinonemethide
• Cycloaddition

A novel synthesis of poly substituted chromenes from various salicylaldehydes and alkynes not having electron withdrawing substituents under mild conditions has been developed. The procedure is applicable for easily available various substituted salicylaldehydes and alkynylsilanes. The present reaction provides versatile access to functionalized 2H-chromenes that would be a useful tool for the synthesis of biologically and photochemically active molecules.

• 出版日期2016-6-1