Mitochondrial deficiency in Cockayne syndrome

作者：Scheibye Knudsen Morten; Croteau Deborah L; Bohr Vilhelm A^*

来源：Mechanisms of Ageing and Development, 2013, 134(5-6): 275-283.

DOI：10.1016/j.mad.2013.02.007

• Cockayne syndrome
• Mitochondria
• Aging
• Transcription
• DNA repair

Cockayne syndrome is a rare inherited disorder characterized by accelerated aging, cachectic dwarfism and many other features. Recent work has implicated mitochondrial dysfunction in the pathogenesis of this disease. This is particularly interesting since mitochondrial deficiencies are believed to be important in the aging process. In this review, we discuss recent findings of mitochondrial pathology in Cockayne syndrome and suggest possible mechanisms for the mitochondrial dysfunction. Published by Elsevier Ireland Ltd.

• 出版日期2013-6