Membrane type 1-matrix metalloproteinase: Substrate diversity in pericellular proteolysis

作者：Barbolina Maria V; Stack M Sharon^*

来源：Seminars in Cell & Developmental Biology, 2008, 19(1): 24-33.

DOI：10.1016/j.semcdb.2007.06.008

• membrane type 1-matrix metalloproteinase
• pericellular proteolysis
• extracellular matrix

Enzymes in the matrix metalloproteinase (MMP) family have been linked to key events in developmental biology for almost 50 years. Biochemical, cellular and in vivo analyses have established that pericellular proteolysis contributes to numerous aspects of ontogeny including ovulation, fertilization, implantation, cellular migration, tissue remodeling and repair. Surface anchoring of proteinase activity provides spatial restrictions on substrate targeting. This review will utilize membrane type 1 MMP (MT1-MMP) as an example to highlight substrate diversity in pericellular proteolysis catalyzed by a membrane anchored MMP.

• 出版日期2008-2
• 单位西北大学