Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

作者：Wu Semon; Hsu Lung An; Teng Ming Sheng; Lin Jeng Feng; Chang Hsien Hsun; Sun Yu Chen; Chen Hsuan Pu; Ko Yu Lin^*

来源：BMC Medical Genetics, 2012, 13: 115.

DOI：10.1186/1471-2350-13-115

• E-selectin
• Genetic association study
• Polymorphism
• Matrix metalloproteinase 9
• Haplotype
• Interaction

Background: E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals. %26lt;br%26gt;Methods: Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed. %26lt;br%26gt;Results: SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P %26lt; 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511). %26lt;br%26gt;Conclusion: SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.

• 出版日期2012-11-29
• 单位长春大学