科研之友
微信
新浪微博
Facebook
分享链接
摘要
A mild and highly efficient ZnCl2-catalyzed direct alkylation of active methylene compounds with benzylic and allylic alcohols has been reported. The alkylation was carried out in the presence of sub-stoichiometric amounts of anhydrous ZnCl2 (5 similar to 10 mol%) under reflux in dichloromethane with high yields. It is an easy handling and atomic-economic reaction and water is the only side product. The possible mechanism for this direct alkylation has preliminary studied as well.
