A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer's Disease: Preliminary Results from a Neuroimaging Study

作者：Castellano Christian Alexandre^*; Paquet Nancy; Dionne Isabelle J; Imbeault Helene; Langlois Francis; Croteau Etienne; Tremblay Sebastien; Fortier Melanie; Matte J Jacques; Lacombe Guy; Fueloep Tamas; Bocti Christian; Cunnane Stephen C

来源：Journal of Alzheimer's Disease, 2017, 56(4): 1459-1468.

DOI：10.3233/JAD-161163

• Acetoacetate
• aerobic training
• Alzheimer's disease
• brain energy
• cognition
• ketones
• neuroimaging
• PET

Background: Aerobic training has some benefits for delaying the onset or progression of Alzheimer's disease (AD). Little is known about the implication of the brain's two main fuels, glucose and ketones (acetoacetate), associated with these benefits.
Objective: To determine whether aerobic exercise training modifies brain energy metabolism in mild AD.
Methods: In this uncontrolled study, ten patients with mild AD participated in a 3-month, individualized, moderate-intensity aerobic training on a treadmill (Walking). Quantitative measurement of brain uptake of glucose (CMRglu) and acetoacetate (CMRacac) using neuroimaging and cognitive testing were done before and after the Walking program.
Results: Four men and six women with an average global cognitive score (MMSE) of 26/30 and an average age of 73 y completed the Walking program. Average total distance and treadmill speed were 8 km/week and 4 km/h, respectively. Compared to the Baseline, after Walking, CMRacac was three-fold higher (0.6+/-0.4 versus 0.2+/-0.1 mu mol/100 g/min; p = 0.01). Plasma acetoacetate concentration and the blood-to-brain acetoacetate influx rate constant were also increased by 2-3-fold (all p <= 0.03). CMRglu was unchanged after Walking (28.0+/-0.1 mu mol/100 g/min; p = 0.96). There was a tendency toward improvement in the Stroop-color naming test (-10% completion time, p = 0.06). Performance on the Trail Making A&B tests was also directly related to plasma acetoacetate and CMRacac (all p <= 0.01).
Conclusion: In mild AD, aerobic training improved brain energy metabolism by increasing ketone uptake and utilization while maintaining brain glucose uptake, and could potentially be associated with some cognitive improvement.

• 出版日期2017