Glass transition dynamics of anti-inflammatory ketoprofen studied by Raman scattering and terahertz time-domain spectroscopy

作者：Shibata Tomohiko^*; Igawa Hikaru; Kim Tae Hyun; Mori Tatsuya; Kojima Seiji

来源：Journal of Molecular Structure, 2014, 1062: 185-188.

DOI：10.1016/j.molstruc.2014.01.050

• Ketoprofen
• Boson peak
• Raman scattering
• THz-TDS
• Glass transition
• Crystal

A liquid-glass transition and a crystalline state of pharmaceutical racemic ketoprofen were studied by Raman scattering and the broadband terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 9 to 260 cm(-1). The low-frequency Raman scattering spectra clearly shows the remarkable change related to a liquid-glass transition at about T-g = 267 K. After melt-quenching at liquid nitrogen temperature, a boson peak appears at about 16.5 cm(-1) near and below T-g and the intensity of quasi-elastic scattering related to structural relaxation increases markedly on heating. The crystalline racemic ketoprofen of "conformer A" shows the noncoincidence effect of mode frequencies below 200 cm(-1) between Raman scattering spectra and dielectric spectra observed by THz-TDS.

• 出版日期2014-3-24