Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music

作者：Ukkola Vuoti Liisa; Oikkonen Jaana; Onkamo Paivi; Karma Kai; Raijas Pirre; Jarvela Irma^*

来源：Journal of Human Genetics, 2011, 56(4): 324-329.

DOI：10.1038/jhg.2011.13

• association
• AVPR1A
• genetic
• musical aptitude
• music listening
• SLC6A4

Music is listened in all cultures. We hypothesize that willingness to produce and perceive sound and music is social communication that needs musical aptitude. Here, listening to music was surveyed using a web-based questionnaire and musical aptitude using the auditory structuring ability test (Karma Music test) and Carl Seashores tests for pitch and for time. Three highly polymorphic microsatellite markers (RS3, RS1 and AVR) of the arginine vasopressin receptor 1A (AVPR1A) gene, previously associated with social communication and attachment, were genotyped and analyzed in 31 Finnish families (n=437 members) using family-based association analysis. A positive association between the AVPR1A haplotype (RS1 and AVR) and active current listening to music (permuted P=0.0019) was observed. Other AVPR1A haplotype (RS3 and AVR) showed association with lifelong active listening to music (permuted P=0.0022). In addition to AVPR1A, two polymorphisms (5-HTTLPR and variable number of tandem repeat) of human serotonin transporter gene (SLC6A4), a candidate gene for many neuropsychiatric disorders and previously associated with emotional processing, were analyzed. No association between listening to music and the polymorphisms of SLC6A4 were detected. The results suggest that willingness to listen to music is related to neurobiological pathways affecting social affiliation and communication. Journal of Human Genetics (2011) 56, 324-329; doi:10.1038/jhg.2011.13; published online 10 February 2011

• 出版日期2011-4