Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans

作者：Marcelino Monica Yonashiro; Borges Felipe Azevedo; Martins Costa Ana Flavia; Singulani Junya de Lacorte; Ribeiro NathanVinicius; Costa Orlandi Caroline Barcelos; Garms Bruna Cambraia; Mendes Giannini Maria Jose Soares; Herculano Rondinelli Donizetti; Fusco Almeida Ana Marisa^*

来源：Future Microbiology, 2018, 13(3): 359-367.

DOI：10.2217/fmb-2017-0154

• Candida albicans
• fluconazole
• natural rubber latex (NRL)

Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Materials & methods: Fluconazole-loaded NRL membrane was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. Conclusion: The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.

• 出版日期2018-3