INGESTION OF TRANSIENT RECEPTOR POTENTIAL CHANNEL AGONISTS ATTENUATES EXERCISE-INDUCED MUSCLE CRAMPS

作者：Craighead Daniel H^*; Shank Sean W; Gottschall Jinger S; Passe Dennis H; Murray Bob; Alexander Lacy M; Kenney W Larry

来源：Muscle & Nerve, 2017, 56(3): 379-385.

DOI：10.1002/mus.25611

• alpha-motor neuron hyperexcitability
• EMG
• exercise-associated muscle cramp
• TRPA1
• TRPV1

Introduction: Exercise-associated muscle cramping (EAMC) is a poorly understood problem that is neuromuscular in origin. Ingestion of transient receptor potential (TRP) channel agonists has been efficacious in attenuating electrically induced muscle cramps. This study examines the effect of TRP agonist ingestion on voluntarily induced EAMC and motor function. Methods: Study 1: Thirty-nine participants completed 2 trials after ingesting TRP agonist-containing active treatment (A), or vehicle (V) control. Cramping in the triceps surae muscle was induced via voluntary isometric contraction. Study 2: After ingesting A or V, 31 participants performed kinematic and psychomotor tests of manual dexterity. Results: A increased pre-cramp contraction duration (A, 36.9 +/- 4.1 s; V, 27.8 +/- 3.1 s), decreased cramp EMG area under the curve (A, 37.3 +/- 7.7 % EMG(max) . s; V,77.2 +/- 17.7 % EMGmax . s), increased contraction force to produce the cramp (A, 13.8 +/- 1.8 kg; V, 9.9 +/- 1.6 kg), and decreased postcramp soreness (A, 4.1 6 +/- 0.3 arbitrary units (a.u.); V, 4.7 +/- 0.3 a.u.). Kinematic and psychomotor tests were not affected. Discussion: TRP agonist ingestion attenuated EAMC characteristics without affecting motor function.

• 出版日期2017-9