Autopsy case of delayed anaphylactic shock due to contrast medium

作者：Nagai Yayoi^*; Tanaka Yuko; Nakazato Yoichi; Sugawara Nobuyuki; Arai Miho; Okada Etsuko; Koyama Yoshinari; Hinohara Hiroshi; Yamamoto Koujirou; Kurabayashi Masahiko; Nojima Yoshihisa; Ishikawa Osamu

来源：Journal of Dermatology, 2012, 39(10): 852-854.

DOI：10.1111/j.1346-8138.2012.01585.x

• allergy
• autopsy
• biphasic reaction
• contrast medium
• delayed anaphylactic shock
• fatal

We report an autopsy case of delayed anaphylactic shock due to contrast medium. A 17-year-old Japanese man underwent angiography using non-ionic contrast medium under the suspected diagnosis of Buergers disease. Initial symptoms appeared 6 h after the administration of the contrast medium, and death was confirmed 11 h later. Considering the clinical course and the results of the autopsy, we concluded that the direct cause of the patients death was severe acute circulatory failure due to a delayed allergic reaction to the contrast medium. The reported incidence of serious delayed reactions or biphasic reactions to non-ionic contrast medium is extremely low; however, we should be aware of such rare adverse reactions.

• 出版日期2012-10