A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants

作者：Macon Anthony L B; Kim Taek B; Valliant Esther M; Goetschius Kathryn; Brow Richard K; Day Delbert E; Hoppe Alexander; Boccaccini Aldo R; Kim Ill Yong; Ohtsuki Chikara; Kokubo Tadashi; Osaka Akiyoshi; Vallet Regi Maria; Arcos Daniel; Fraile Leandro; Salinas Antonio J; Teixeira Alexandra V; Vueva Yuliya; Almeida Rui M; Miola Marta; Vitale Brovarone Chiara; Verne Enrica; Hoeland Wolfram; Jones Julian R^*

来源：Journal of Materials Science: Materials in Medicine , 2015, 26(2): 115.

DOI：10.1007/s10856-015-5403-9

The aim of this study was to propose and validate a new unified method for testing dissolution rates of bioactive glasses and their variants, and the formation of calcium phosphate layer formation on their surface, which is an indicator of bioactivity. At present, comparison in the literature is difficult as many groups use different testing protocols. An ISO standard covers the use of simulated body fluid on standard shape materials but it does not take into account that bioactive glasses can have very different specific surface areas, as for glass powders. Validation of the proposed modified test was through round robin testing and comparison to the ISO standard where appropriate. The proposed test uses fixed mass per solution volume ratio and agitated solution. The round robin study showed differences in hydroxyapatite nucleation on glasses of different composition and between glasses of the same composition but different particle size. The results were reproducible between research facilities. Researchers should use this method when testing new glasses, or their variants, to enable comparison between the literature in the future.

• 出版日期2015-2