Blood platelets and biological response to 'danger' signals - and subsequent inflammation: Towards a new paradigm?

作者：Garraud O^*; Damien P; Berthet J; Arthaud C A; Hamzeh Cognasse H; Cognasse F

来源：Transfusion Clinique et Biologique, 2011, 18(2): 165-173.

DOI：10.1016/j.tracli.2011.02.012

• Platelets
• Inflammation
• Innate immunity
• Toll-like receptors
• Infection
• Haemostasis
• Cell signaling
• Tissue repair

Blood platelets are cellular elements of primary haemostasis. During the last decade research on platelets has been subsequently based on this paradigm, with separate observations on issues such as the ability for platelets to bind infectious agents or even engulf them, to drop in counts in case of evolving infectious processes, etc. More recently, novel work has set up bases for novel functions for platelets, as members of functional immune cells, principally in innate immunity but capable of influencing adaptive immunity. Platelets are thus essential to haemostasis and to inflammation, questioning their essential functionality and the set up of a novel paradigm: could platelets be tissue-repairing cells? Such an assumption would open an entire new field of investigations. The present "State of the Art" essay attempts to discuss the main arguments on this.

• 出版日期2011-4