Four-component synthesis of ferrocene-containing 1,3,4-oxadiazoles from N-isocyaniminotriphenylphosphorane (Ph3PNNC), a primary amine, a cyclic ketone and ferrocene carboxylic acid

作者：Ashtary Mona; Ramazani Ali^*; Kazemizadeh AliReza; Shajari Nahid; Fattahi Nadia; Joo Sang Woo^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2016, 191(10): 1402-1407.

DOI：10.1080/10426507.2016.1209503

• N-Isocyaniminotrip-henylphos-phorane (Ph3PNNC)
• ferrocene carboxylic acid
• cyclic ketone
• primary amine
• 1,3,4-oxadiazole
• aza-Wittig reaction

The 1:1 imine intermediate created by the addition of a primary amine to a cyclic ketone is trapped by N-isocyaniminotriphenylphosphorane (Ph3PNNC) in the presence of ferrocene carboxylic acid and the corresponding iminophosphorane intermediate was formed. Afterwards, ferrocene containing 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reaction proceeded under mild conditions at room temperature.
[GRAPHICS]
.

• 出版日期2016