A Strategy to Synthesize Taxol Side Chain and (-)-epi Cytoxazone via Chiral Bronsted Acid-Rh-2(OAc)(4) Co-catalyzed Enantioselective Three-Component Reactions

作者：Qian, Yu; Xu, Xinfang; Jiang, Liqin; Prajapati, Dipak; Hu, Wenhao^*

来源：Journal of Organic Chemistry, 2010, 75(21): 7483-7486.

DOI：10.1021/jo101559p

• Diastereo-selectivity
• Efficient synthesis
• Enantioselective
• Hydroxyl acids
• Optically Active
• Reaction system
• Taxol side chain
• Three component reactions

A new approach to synthesize optically active beta-amino-alpha-hydroxyl acid derivatives via chiral Bronsted (OAc)(4) cocatalyzed three-component reactions of diazo acetates with alcohols and imines is reported. A matched reaction system was identified to give the products in moderate diastereoselectivity and good enantioselectivity. Application of this methodology is demonstrated in the efficient synthesis of a taxol side chain and (-)-epi-cytoxazone.

• 出版日期2010-11-5
• 单位华东师范大学