Activity of Raphe Serotonergic Neurons Controls Emotional Behaviors

作者：Teissier Anne; Chemiakine Alexei; Inbar Benjamin; Bagchi Sneha; Ray Russell S; Palmiter Richard D; Dymecki Susan M; Moore Holly; Ansorge Mark S^*

来源：Cell Reports, 2015, 13(9): 1965-1976.

DOI：10.1016/j.celrep.2015.10.061

Despite the well-established role of serotonin signaling in mood regulation, causal relationships between serotonergic neuronal activity and behavior remain poorly understood. Using a pharmacogenetic approach, we find that selectively increasing serotonergic neuronal activity in wild-type mice is anxiogenic and reduces floating in the forced-swim test, whereas inhibition has no effect on the same measures. In a developmental mouse model of altered emotional behavior, increased anxiety and depression-like behaviors correlate with reduced dorsal raphe and increased median raphe serotonergic activity. These mice display blunted responses to serotonergic stimulation and behavioral rescues through serotonergic inhibition. Furthermore, we identify opposing consequences of dorsal versus median raphe serotonergic neuron inhibition on floating behavior, together suggesting that median raphe hyperactivity increases anxiety, whereas a low dorsal/median raphe serotonergic activity ratio increases depression-like behavior. Thus, we find a critical role of serotonergic neuronal activity in emotional regulation and uncover opposing roles of median and dorsal raphe function.

• 出版日期2015-12-1