Central Corneal Thickness Measurements With Fourier-Domain Optical Coherence Tomography Versus Ultrasonic Pachymetry and Rotating Scheimpflug Camera

作者：Ishibazawa Akihiro; Igarashi Sho^*; Hanada Kazuomi; Nagaoka Taiji; Ishiko Satoshi; Ito Haruna; Yoshida Akitoshi

来源：Cornea, 2011, 30(6): 615-619.

DOI：10.1097/ICO.0b013e3181d00800

• central corneal thickness
• Fourier-domain optical coherence tomography
• ultrasonic pachymetry
• rotating Scheimpflug camera

Purpose: To compare the accuracy and repeatability of Fourier-domain optical coherence tomography (FD-OCT) with ultrasonic pachymetry (USP) and a rotating Scheimpflug camera for measuring the central corneal thickness (CCT).
Methods: The CCT was measured in 30 subjects (30 normal corneas) by the same examiner using RTVue-100 FD-OCT with an anterior segment adaptor, Pentacam rotating Scheimpflug camera, and SP-2000 USP. Two examiners obtained one FD-OCT measurement from 10 eyes of 5 subjects to assess interexaminer reproducibility.
Results: The mean CCT (+/- SD) measured by FD-OCT, USP, and the Pentacam were 530 +/- 33, 544 +/- 34, and 552 +/- 35 mu m, respectively. Significant correlations were found between FD-OCT and USP (r = 0.97; P < 0.0001), FD-OCT and Pentacam (r = 0.97; P < 0.0001), and USP and Pentacam (r = 0.96; P < 0.0001). Pairwise comparisons showed that the FD-OCT CCT measurement was significantly thinner than those of the other 2 methods (P < 0.001 for all comparisons). Regarding intraexaminer repeatability, the intraclass correlation coefficients ranged between 0.97 and 0.98. There was high repeatability of the CCT measurements with all methods. FD-OCT also had high interexaminer reproducibility (intraclass correlation coefficient = 0.98).
Conclusions: RTVue-100 FD-OCT may be a useful alternative for measuring the CCT; however, it significantly underestimates the CCT compared with the USP and the Pentacam with slight differences. Although highly correlated, the measurements are not directly interchangeable in clinical practice.

• 出版日期2011-6