A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

作者：Li, Dong-Peng; Wang, Zhao-Yang; Cao, Xiang-Jian; Cui, Jie; Wang, Xin; Cui, Hao-Zhong; Miao, Jun-Ying^*; Zhao, Bao-Xiang^*

来源：Chemical communications, 2016, 52(13): 2760-2763.

DOI：10.1039/c5cc09092j

• LIVING CELLS
• IN-VIVO
• HYDROGEN-SULFIDE
• SO2 DERIVATIVES
• SERUM SULFITE
• PHOSPHORESCENT PROBE
• SELECTIVE DETECTION
• SENSING MECHANISM
• AQUEOUS-SOLUTION
• RAPID DETECTION

A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3-/SO32-) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3-/SO32-. Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.

• 出版日期2016
• 单位山东大学