科研之友
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摘要
Benzimidazole is an interesting heterocyclic compound because it is found in various drugs such as bifeprunox, pimozide, droperidol, etc. The efficacy of substituted benzimidazoles in the treatment of psychoses is well known. Substituted benzimidazole moieties are established pharmacophores in schizophrenia chemotherapy. Benzimidazole derivatives have proven to be of great potential in determining a wide range of activity by binding to various receptors. In addition, piperazinyl moieties linked to benzimidazole enhances the activity at the DA receptors to a greater extent. Various routes have been adopted for the synthesis of derivatives having comparable anti-psychotic activity at various receptors. Dopamine receptors have the potential to mediate activity to varying extent through the binding of ligands, upon it. In this review, binding affinity values of various substituted parent compounds to various dopamine receptors as well as few 5-HT receptors with antipsychotic activity have been tabulated and the synthetic scheme of the same has been shown. This review is summarized to know about various benzimidazolo-piperazinyl ligands that have potential to bind at the dopamine receptors.
- 出版日期2013-2
