A Chiral Solvent Effect in Asymmetric Organocatalysis

作者:North Michael*; Villuendas Pedro
来源:Organic Letters, 2010, 12(10): 2378-2381.
DOI:10.1021/ol1007313

摘要

Proline-catalyzed aldol reactions between enolizable ketones and aromatic aldehydes can be carried out in propylene carbonate. When enantiomerically pure propylene carbonate is used, the combination of (R)-proline and (R)-propylene carbonate constitutes a matched pair, while (S)-proline and (R)-propylene carbonate constitutes a mismatched pair.

  • 出版日期2010-5-21