An Autopsy Case of Two Distinct, Acquired Drug Resistance Mechanisms in Epidermal Growth Factor Receptor-mutant Lung Adenocarcinoma: Small Cell Carcinoma Transformation and Epidermal Growth Factor Receptor T790M Mutation

作者：Furugen Makoto^*; Uechi Kayoko; Hirai Jun; Aoyama Hajime; Saio Masanao; Yoshimi Naoki; Kinjo Takeshi; Miyagi Kazuya; Haranaga Shusaku; Higa Futoshi; Tateyama Masao; Fujita Jiro

来源：Internal Medicine, 2015, 54(19): 2491-2496.

DOI：10.2169/internalmedicine.54.5481

• EGFR mutation
• lung adenocarcinoma
• EGFR-TKI
• small cell carcinoma transformation
• EGFR T790M mutation

We herein describe the case of a 63-year-old man who died from relapsed epidermal growth factor receptor gene (EGFR) exon 19 deletion lung adenocarcinoma treated with erlotinib. According to the autopsy results, he was confirmed to have small cell carcinoma without the EGFR T790M mutation in his pancreas and left kidney metastatic specimens, while the adenocarcinoma metastatic lesion in his right kidney had the EGFR T790M mutation; both retained the somatic EGFR exon 19 deletion. We herein report an autopsy case of resistance to an EGFR tyrosine kinase inhibitor via small cell carcinoma transformation and the EGFR T790M mutation in separate metastatic organs.

• 出版日期2015