科研之友
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摘要
A unique one-pot synthesis of cyclic cis-1,2-amino alcohols from trans-1,2-azido alcohol precursors was developed. The key step is highlighted by the stereoselective reduction of the cyclic alpha-alkoxy imines, which could be prepared from the corresponding azides by ruthenium catalysis under photolytic conditions. Remarkably, this unprecedented reaction pathway offers a stereodivergent access to structurally diverse cyclic 1,2-amino alcohols.
- 出版日期2015-5-4
