Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T

作者：Joshi Gagan^*; Biederman Joseph; Wozniak Janet; Goldin Rachel L; Crowley Dave; Furtak Stephannie; Lukas Scott E; Goenenc Atilla

来源：European Archives of Psychiatry and Clinical Neuroscience, 2013, 263(5): 379-384.

DOI：10.1007/s00406-012-0369-9

• Autistic disorder
• Youth
• Magnetic resonance spectroscopy
• Glutamate

The pilot study aimed at examining the neural glutamatergic activity in autism. Seven adolescent males (mean age: 14 +/- A 1.8; age range: 12-17 years) with intact intellectual capacity (mean IQ: 108 +/- A 14.26; IQ range: 85-127) suffering from autistic disorder and an equal number of age- and sex-matched healthy controls underwent a two-dimensional magnetic resonance spectroscopy scan at 4T. Results indicated significantly high glutamate (Glu) levels in the anterior cingulate cortex of autistic disorder versus control subjects (paired t test p = 0.01) and a trend for lower Glu in the right medial temporal lobe, which was not statistically different between the groups (paired t test p = 0.06). These preliminary findings support the glutamatergic dysregulation hypothesis in autism and need to be replicated in a larger sample.

• 出版日期2013-8