科研之友
微信
新浪微博
Facebook
分享链接
摘要
New evidence has revealed interesting aspects of how the Wnt-beta-catenin pathway controls self-renewal and lineage differentiation of pluripotent embryonic stem cells. Although Wnt-beta-catenin signaling is dispensable for the self-renewal of naive mouse embryonic stem cells, it facilitates their expansion and resistance to differentiation through an unconventional dual mechanism involving the transcriptional repressor T cell factor (TCF) 3 and the transcriptional activator TCF1.
- 出版日期2011-10-4
