Does naloxone alone increase resuscitation rate during cardiopulmonary resuscitation in a rat asphyxia model?

作者：Chen, Meng Hua^*; Liu, Tang Wei; Xie, Lu; Song, Feng Qing; He, Tao

来源：American Journal of Emergency Medicine, 2006, 24(5): 567-572.

DOI：10.1016/j.ajem.2006.01.017

Cardiac arrest was induced with asphyxia to identify if naloxone alone increases resuscitation rate during cardiopulmonary resuscitation in a rat asphyxia model. The animals were randomized into either a saline group (Sal-gro, treated with normal saline 1 ml iv, n = 8), a low-dose naloxone group (treated with naloxone 0.5 mg/kg iv, n = 8), or a high-dose naloxone group (HN-gro, treated with naloxone 1 mg/kg iv, n = 8) in a blinded fashion during resuscitation. At the end of 10 minutes of asphyxia, cardiopulmonary resuscitation was started, and each drug was administered at the same time. The rate of restoration of spontaneous circulation was seen in 1 of 8, 3 of 8, and 7 of 8 animals in the Sal-gro, LN-gro, and RN-gro, respectively. The rate of restoration of spontaneous circulation in HN-gro was significantly higher than that in Sal-gro (P < .05). Naloxone (1 mg/kg) alone can increase resuscitation rate following asphyxial cardiac arrest in rats.

• 出版日期2006-9
• 单位广西医科大学