Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study

作者：Hishida Asahi^*; Morita Emi; Naito Mariko; Okada Rieko; Wakai Kenji; Matsuo Keitaro; Nakamura Kazuyo; Takashima Naoyuki; Suzuki Sadao; Takezaki Toshiro; Mikami Haruo; Ohnaka Keizo; Watanabe Yoshiyuki; Uemura Hirokazu; Kubo Michiaki; Tanaka Hideo; Hamajima Nobuyuki

来源：Endocrine Journal, 2012, 59(7): 589-599.

DOI：10.1507/endocrj.EJ11-0310

• APOA5
• GCK
• Single nucleotide polymorphisms
• Dyslipidemia
• Dysglycemia

This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with scrum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) %26gt;= 150 mg/dL and/or HDL-cholesterol (HDL-C) %26lt;40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) %26gt;= 110 mg/dL. When those with APOA5 -1131 T/Tor 553 G/G were defined as references, those with APOA5 -1131 TIC, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FIG and HDL-C levels were significantly associated with the APOA5T-1131C and G553Tpolymorphisms, FIG with the GCKR rs780094 and rs1260326 polyrnorphisms, and FBS with the GCICR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake %26gt;= 25% of total energy for the risk of dyslipidemia was observed. Our cross-sectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.

• 出版日期2012-7-20