New Quinoline-Based Compounds for Analgesic and Anti-Inflammatory Evaluation

作者：Khidre Rizk Elsayed; Abdel Wahab Bakr Fathy^*; Badria Farid Abdel Rehem

来源：Letters in Drug Design and Discovery, 2011, 8(7): 640-648.

• Quinoline
• Pyranes
• Knoevenagel reaction
• Analgesic
• Anti-inflammatory
• X-ray analysis

In this study, 2-chloroquinolin-3-carbaldehyde 1 was used as a synthon for the synthesis of some new quinoline; pyrane; indeno[1,2-b]pyrano[2,3-b]quinoline heterocycles. The anti-inflammatory and analgesic activities of the synthesized compounds were evaluated using carrageenan-induced paw edema and writhing assays. The obtained data indicated that the majority of the tested compounds exhibited both analgesic and anti-inflammatory activities, particularly compounds 2 and 6 showed a comparable effect to a well known analgesic and anti-inflammatory, diclofenac sodium.

• 出版日期2011-8