Antibacterial activity of an epoxidised prenylated cinnamaldehdye derivative from Vepris glomerata

作者：Kiplimo Joyce J; Koorb****ly Neil A^*

来源：Phytochemistry Letters, 2012, 5(3): 438-442.

DOI：10.1016/j.phytol.2012.03.017

• Vepris glomerata
• Rutaceae
• Glomeral
• Antibacterial activity

A prenylated cinnamaldehyde (glomeral), together with the known p-hydroxycinnamic acid, caffeic acid, methyl cinnamate, hesperetin, scoparone, skimmianine, syringaresinol and two limonoids (limonin and limonyl acetate) were isolated from the roots and stem bark of Vepris glomerata. The antibacterial assay of the isolated compounds indicated an inhibition zone, ranging from 8 to 16 mm, against standard strains of Staphylococcus aureus (ATCC 29213, 25923) and Shigella dysentrieae. Glomeral inhibited the growth of S. aureus and S. dysentrieae at low concentrations (MIC of 2 mu g/mL and 0.4 mu g/mL respectively). Of the other compounds tested, hesperetin displayed good antibacterial activity, the limonoids, scoparone and skimmianine displayed moderate antibacterial activity and the cinnamic acid derivatives were inactive against the test pathogens. This study provides a rationale for the use of V. glomerata in its treatment of bacterial infections.

• 出版日期2012-9