Adenovirus-mediated human brain-derived neurotrophic factor gene-modified bone marrow mesenchymal stem cell transplantation for spinal cord injury

作者：Wang, Changsheng; Lin, Jianhua^*; Wu, Chaoyang; Chen, Rongsheng

来源：Neural Regeneration Research, 2011, 6(16): 1211-1216.

DOI：10.3969/j.issn.1673-5374.2011.16.002

• brain-derived neurotrophic factor
• bone marrow mesenchymal stem cells
• gene modification
• intravenous transplantation
• spinal cord injury
• neural regeneration

Rat bone marrow mesenchymal stem cells expressing brain-derived neurotrophic factor were successfully obtained using a gene transfection method, then intravenously transplanted into rats with spinal cord injury. At 1, 3, and 5 weeks after transplantation, the expression of brain-derived neurotrophic factor and neurofilament-200 was upregulated in the injured spinal cord, spinal cord injury was alleviated, and Basso-Beattie-Bresnahan scores of hindlimb motor function were significantly increased. This evidence suggested that intravenous transplantation of adenovirus-mediated brain-derived neurotrophic factor gene-modified rat bone marrow mesenchymal stem cells could play a dual role, simultaneously providing neural stem cells and neurotrophic factors.

• 出版日期2011-7-25
• 单位福建医科大学