Ubiquitin-proteasome system - Proteins interacting with the 26S proteasome

作者：Hartmann Petersen R; Gordon C^*

来源：Cellular and Molecular Life Sciences, 2004, 61(13): 1589-1595.

DOI：10.1007/s00018-004-4132-x

• proteolysis
• 26S proteasome
• ubiquitin
• multi-ubiquitin binding proteins
• UBA domain
• UIM domain
• UBL domain

The 26S proteasome is the multi-protein protease that recognizes and degrades ubiquitinylated substrates targeted for destruction by the ubiquitin pathway. In addition to the well-documented subunit organization of the 26S holoenzyme, it is clear that a number of other proteins transiently associate with the 26S complex. These transiently associated proteins confer a number of different roles such as substrate presentation, cleavage of the multi-ubiquitin chain from the protein substrate and turnover of misfolded proteins. Such activities are essential for the 26S proteasome to efficiently fulfill its intracellular function in protein degradation.

• 出版日期2004-6