Hepatitis e in the south west of France in individuals who have never visited an endemic area

作者：Mansuy JM^*; Peron JM; Abravanel F; Poirson H; Dubois M; Miedouge M; Vischi F; Alric L; Vinel JP; Izopet J

来源：Journal of Medical Virology, 2004, 74(3): 419-424.

DOI：10.1002/jmv.20208

• hepatitis E
• France
• autochthonous
• real time PCR
• genotype 3

A total of 431 consecutive patients from the Midi Pyrenees area with acute hepatitis with unknown etiology in 2001-2002 were tested for the presence of immunoglobulin G-class (IgG) anti-hepatitis E virus (HEV) antibodies. Forty-six (10.7%) had anti-HEV IgG, and the results were questionable for a further 17 (3.9%). Real time PCR based on TaqMan detection was used to identify HEV genome fragments in the serum of patients with positive or questionable anti-HEV serology. HEV RNA was found in 25.4% of cases. All amplification products were sequenced and analyzed. Phylogenetic analysis revealed that all the strains were genotype 3. In conclusion, virological and epidemiological data indicate that genotype 3 viruses are circulating in the south west part of France (Midi-Pyrenees) in patients with acute hepatitis and who have not visited recently areas in which HEV is endemic.

• 出版日期2004-11