MicroRNAs, major players in B cells homeostasis and function

作者：Danger Richard; Braze Faouzi; Giral Magali; Soulillouz Jean Paul; Brouard Sophie^*

来源：Frontiers in Immunology, 2014, 5: 98.

DOI：10.3389/fimmu.2014.00098

• B cell
• immunology
• immune disorder
• microRNA
• gene-expression regulation

As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and function is needed in order to decipher their immune-modulatory roles, notably with the recent highlighting of regulatory B cells. microRNAs (miRNAs), key factors in various biological and pathological processes, have been shown to be essential for B-cell homeostasis, and therefore understanding their participation in B-cell biology could help identify biomarkers and contribute toward curing B-cell-related immune disorders. This review aims to report studies casting light on the roles played by miRNAs in B-cell lineage and function and B-cell-related immune pathologies.

• 出版日期2014-3-11