APL-1, A CAENORHABDITIS-ELEGANS GENE ENCODING A PROTEIN RELATED TO THE HUMAN BETA-AMYLOID PROTEIN-PRECURSOR

作者：DAIGLE I; LI C

来源：Proceedings of the National Academy of Sciences of the United States of America, 1993, 90(24): 12045-12049.

DOI：10.1073/pnas.90.24.12045

The major component of senile plaques found in the brains of Alzheimer disease patients is the beta-amyloid peptide, which is derived from a larger amyloid precursor protein (APP). Recently, a number of APP and APP-related proteins have been identified in different organisms and constitute the family of APP proteins. We have isolated several cDNAs encoding an APP-related protein in the nematode Caenorhabditis elegans and have designated the corresponding gene as apl-1. The apl-1 transcripts undergo two forms of posttranscriptional modification: trans-splicing and alternative polyadenylylation. In vitro translation of an apl-1 cDNA results in a protein of approximately the expected size. Similar to the Drosophila, human, and mouse APP-related proteins, APL-1 does not appear to contain the beta-amyloid peptide. Because APP-related proteins seem to be conserved through evolution, the apl-1 gene from C. elegans should be important for determining the normal function of human APP.

• 出版日期1993-12-15