Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease

作者：Xu, Yujun; Ding, Hu; Peng, Jia; Cui, Guanglin; Liu, Lei; Cianflone, Katherine; Wang, Dao Wen^*

来源：Pharmacogenetics and Genomics, 2011, 21(8): 489-494.

DOI：10.1097/FPC.0b013e3283485eb2

• association
• coronary artery disease
• CYP2J2
• EPHX2
• G-50T
• R287Q
• single nucleotide polymorphism

Objective Common polymorphisms within cytochrome P450 2J2 (CYP2J2) and epoxide hydrolase 2 (EPHX2), which are involved in the generation or hydrolysis of epoxyeicosatrienoic acids, may determine susceptibility to the development of cardiovascular disease. To derive a more precise estimation of their relationship, we undertook a case-control study as well as a meta-analysis to assess possible associations of coronary artery disease (CAD) risk with CYP2J2 and EPHX2 genetic variations. @@@ Methods Associations among four single nucleotide polymorphisms in CYP2J2 and five in EPHX2 with CAD were examined in a total of 1344 cases and 1267 ethnically and geographically matched controls. To further confirm the effect of two functional variants (G-50T and R287Q) in the development of CAD, we conducted a meta-analysis including seven studies on G-50T polymorphism and six studies on R287Q polymorphism before June 2010. @@@ Results No significant association between common polymorphisms within these two genes and CAD was observed in our sample, either using methods of single-locus analysis or haplotype-based analysis. In addition, no association was detected in our meta-analysis between these two functional variants and the risk of developing CAD. @@@ Conclusion This case-control study as well as meta-analysis suggested no association between CYP2J2 G-50T and EPHX2 R287Q and the risk of developing CAD.

• 出版日期2011-8
• 单位华中科技大学