Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives; a case report

作者：Idorn Thomas^*; Schejbel Lone; Rydahl Casper; Heaf James Goya; Jolvig Karen Riis; Bergstrom Marie; Garred Peter; Kamper Anne Lise

来源：BMC Nephrology, 2012, 13: 64.

DOI：10.1186/1471-2369-13-64

• Aetiology
• Anti-glomerular basement membrane glomerulonephritis
• Atypical haemolytic-uremic syndrome
• Thrombotic microangiopathy

Background: Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy are rare diseases with no known coherence.
Case Presentation: A daughter and her biological mother were diagnosed with pregnancy-induced thrombotic microangiopathy and anti-glomerular basement membrane glomerulonephritis, respectively. Both developed end-stage renal disease. Exploration of a common aetiology included analyses of HLA genotypes, functional and genetic aspects of the complement system, ADAMTS13 activity and screening for autoantibodies. The daughter was heterozygous carrier of the complement factor I G261D mutation, previously described in patients with membranoproliferative glomerulonephritis and atypical haemolytic uremic syndrome. The mother was non-carrier of this mutation. They shared the disease associated complement factor H silent polymorphism Q672Q (79602A > G).
Conclusion: An unequivocal functional or molecular association between these two family cases was not found suggesting that the patients probably share another, so far undiagnosed and unknown, predisposing factor. It seems highly unlikely that two infrequent immunologic diseases would occur by unrelated pathophysiological mechanisms within first degree relatives.

• 出版日期2012-7-26