Antimicrobial activity of fibrinogen and fibrinogen-derived peptides - a novel link between coagulation and innate immunity

作者：Pahlman Lisa I^*; Morgelin Matthias; Kasetty Gopinath; Olin Anders I; Schmidtchen Artur; Herwald Heiko

来源：Thrombosis and Haemostasis, 2013, 109(5): 930-939.

DOI：10.1160/TH12-10-0739

• Innate immunity
• coagulation
• fibrinogen
• infection

Fibrinogen is a key player in the blood coagulation system, and is upon activation with thrombin converted into fibrin that subsequently forms a fibrin clot. In the present study, we investigated the role of fibrinogen in the early innate immune response. Here we show that the viability of fibrinogen-binding bacteria is affected in human plasma activated with thrombin. Moreover, we found that the peptide fragment GHR28 released from the beta-chain of fibrinogen has antimicrobial activity against bacteria that bind fibrinogen to their surface, whereas non-binding strains are unaffected. Notably, bacterial killing was detected in Group A Streptococcus bacteria entrapped in a fibrin clot, suggesting that fibrinogen and coagulation is involved in the early innate immune system to quickly wall off and neutralise invading pathogens.

• 出版日期2013-5