A comparative study of short- and long-TE H-1 MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors

作者：Choi Changho^*; Ganji Sandeep; Hulsey Keith; Madan Akshay; Kovacs Zoltan; Dimitrov Ivan; Zhang Song; Pichumani Kumar; Mendelsohn Dianne; Mickey Bruce; Malloy Craig; Bachoo Robert; DeBerardinis Ralph; Maher Elizabeth

来源：NMR in Biomedicine, 2013, 26(10): 1242-1250.

DOI：10.1002/nbm.2943

• 2-hydroxyglutarate (2HG)
• H-1 MRS
• 3 T
• point-resolved spectroscopy (PRESS)
• short/long TE
• volume-localized simulations
• human brain
• IDH-mutated gliomas

2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE= 97 ms provides higher detectability of 2HG than TE= 35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

• 出版日期2013-10