Membrane dynamics in mammalian embryogenesis: Implication in signal regulation

作者：Wada Yoh^*; Sun Wada Ge Hong; Kawamura Nobuyuki; Yasukawa Jyunichiro

来源：Birth Defects Research Part C: Embryo Today - Reviews , 2016, 108(1): 33-44.

DOI：10.1002/bdrc.21124

• secretory pathway
• endocytosis
• signal transduction
• embryogenesis

Eukaryotes have evolved an array of membrane compartments constituting secretory and endocytic pathways that allow the flow of materials. Both pathways perform important regulatory roles. The secretory pathway is essential for the production of extracellular, secreted signal molecules, but its function is not restricted to a mere route connecting intra- and extracellular compartments. Post-translational modifications also play an integral function in the secretory pathway and are implicated in developmental regulation. The endocytic pathway serves as a platform for relaying signals from the extracellular stimuli to intracellular mediators, and then ultimately inducing signal termination. Here, we discuss recent studies showing that dysfunction in membrane dynamics causes patterning defects in embryogenesis and tissue morphogenesis in mammals. Birth Defects Research (Part C) 108:33-44, 2016.

• 出版日期2016-3