mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis

作者：Buel Gwen R; Kim Sang Gyun; Blenis John^*

来源：Cell Metabolism, 2013, 17(5): 633-635.

DOI：10.1016/j.cmet.2013.04.018

Mechanistic target of rapamycin complex 1 (mTORC1) regulates growth and metabolism by integrating signals from the cellular environment. Ben-Sahra et al. (2013) and Robitaille et al. (2013) demonstrate a role for mTORC1 in nucleotide production via S6K1 phosphorylation of CAD, which catalyzes the initial steps of de novo pyrimidine biosynthesis.

• 出版日期2013-5-7