Development of tip-enhanced optical spectroscopy for biological applications: a review

作者：Elfick Alistair P D^*; Downes Andrew R; Mouras Rabah

来源：Analytical and Bioanalytical Chemistry, 2010, 396(1): 45-52.

DOI：10.1007/s00216-009-3223-9

• TERS
• Raman
• Near-field
• Biological samples
• tip-enhanced CARS

Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.

• 出版日期2010-1