Absence of an Effect of T89 on the Steady-State Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Volunteers

作者：Wang Ping; Sun He^*; Yang Liu; Li Ling Yan; Hao Jing; Ruff Dennis; Guo Zhi Xin

来源：JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 54(2): 234-239.

DOI：10.1002/jcph.209

• T89
• warfarin
• pharmacokinetics
• pharmacodynamics
• interaction

This open-label, multi-dose, single-center, sequential, inpatient study evaluated the effects of a two herb combination drug (T89, Danshen plus Sanqi) on the steady-state pharmacodynamics (PD) and pharmacokinetics (PK) of warfarin in 24 healthy volunteers. Twenty-three subjects attained a stable international normalized ratio (INR) by taking warfarin alone prior to 1-week of added-on use of T89. INR was not increased after the addition of T89 for 7 days (P>.05). The 90% confidence interval (CI) of the geometric mean ratio for maximum plasma concentrations (C-max) and area under curve (AUC(last)) of both R- and S-warfarin when warfarin was administered with or without T89 was within the 0.80 to 1.25 equivalence ratio. These results indicate that T89 has no effect on the steady-state PD and PK of warfarin. Warfarin and T89 dose adjustments are not required when these two drugs are co-administrated in clinical practice.

• 出版日期2014-2
• 单位天津大学