Detection of butane metabolites as an indicator of butane abuse

作者：Kinoshita Hiroshi^*; Tanaka Naoko; Takakura Ayaka; Kumihashi Mitsuru; Jamal Mostofa; Ito Asuka; Kimura Shoji; Tsutsui Kunihiko; Nagasaki Yasushi; Matsubara Shuji; Ameno Kiyoshi

来源：Romanian Journal of Legal Medicine, 2016, 24(3): 216-218.

DOI：10.4323/rjlm.2016.216

• biomarker
• abuse
• volatile substance
• head-space solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME/GC-MS)

We have identified 2-butanol, 2-butanone, and t-butanol with a faint peak of n-butane in a postmortem blood sample from an inhalant abuser by using head-space solid-phase microextraction coupled with gas chromatography mass spectrometry (HS-SPME/GC-MS). The compounds 2-butanol, 2-butanone, and t-butanol are metabolites of n-butane and isobutane. We concluded that the victim had abused volatile gases prior to death. The identification of metabolites of gases in the blood may be a good biomarker of volatile gas abuse.

• 出版日期2016-9