MRI signal changes in the skull base bone after endoscopic nasopharyngectomy for recurrent NPC: A serial study of 9 patients

作者：Li Hui; Wang De ling; Liu Xue wen; Chen Ming yuan; Mo Yun xian; Geng Zhi jun; Xie Chuan miao^*

来源：European Journal of Radiology, 2013, 82(2): 309-315.

DOI：10.1016/j.ejrad.2012.10.022

• Nasopharyngeal carcinoma
• Nasopharyngectomy
• Endoscopy
• Magnetic resonance imaging

Purpose: This study was focused on the serial changes in magnetic resonance images (MRI) of the skull-base bone that occur after endoscopic nasopharyngectomy in patients with local recurrent nasopharyngeal carcinoma (rNPC).
Materials and methods: Nine patients with histologically proven rNPC were enrolled in this study. Two experienced radiologists independently reviewed all presurgical and postsurgical MR images for each patient.
Results: At 36 sites on the skull base, the MRI signal underwent a change after surgery, which took the form of a heterogeneous pattern of hypointense regions with moderate contrast enhancement on T1WI. The onset of changes ranged between 2 weeks and 3 months after surgery. For 21 of the sites, the changes subsided over the course of follow-up, while in 6 they remained stable. At 9 sites, the alteration MRI signal became more pronounced with time. Changes were more common on the homolateral side of the skull base with respect to the recurrent tumor (P < 0.05). The skull-base bone adjacent to the resection boundary had a higher incidence of signal change than nonadjacent areas (P < 0.05).
Conclusions: MRI changes in the skull base bone, having a number of distinguishing characteristics, appear to be a common sequel to endoscopic nasopharyngectomy for rNPC.

• 出版日期2013-2
• 单位中山大学